Endocrine Abstracts

Background: Hobnail variant of papillary thyroid carcinoma (HPTC) has been recently identified. Given the rarity of the variant its characteristics have been studied only in little series, limiting the quality of the data available for its better management. The aims of our retrospective study were 1) to define the clinical and molecular characteristics of a series of HPTC in a monocentric and relatively large series; 2) to define the clinical and molecular characteristics abl...

Background: Follicular-derived thyroid cancers (FDTC) generally have a good prognosis. Nonetheless, a minority of them have an aggressive behavior and develop distant metastases, with increased mortality rates. Pre-surgically available prognostic markers, able to identify this group of patients are still lacking.Materials and methods: The study involved 436 FNA samples with a malignant/suspicious cytology obtained from thyroid nodules in 436 consecutive ...

Background: Papillary thyroid carcinoma (PTC) is the most common malignant tumor of the thyroid gland, accounting for 74–80% of all thyroid cancers. The T1799T>A transversion is an activating mutation of the BRAF oncogene that is common in conventional PTC and specific to it.Aims: To study the prevalence, tumorigenic role and biomolecular implications of rare BRAF variants in a large cohort of patients.Study desig...